Cheyenne Jackson had started off his acting career in Seattle and then moved to New York where he was an understudy for Thoroughly Modern Millie and Aida. He then starred as Matthew in Altar Boyz. Later on, he got the leading role on Broadway in All Shook Up and won a theater world award for it. Since then he has come out in bigger movies and has earned an Academy Award nomination for United 93.
- Jackson was dubbed by the NY Post as Broadway's sexiest man.
- Jackson had previously worked for Ryan Murphy, with the role of Dustin Goolsby, the coach of "Vocal Adrenaline", on the second season of Glee.
- He is one of the six members of the AHS Repertory Company to be credited in the main cast in every season he appeared in.
- All characters he portrayed in American Horror Story violently died before the end of each season they appeared on. Coincidentally, three of them died after having their throats slit. Two of them were murdered by characters portrayed by Kathy Bates.
- Checking In - Will Drake
- Chutes and Ladders - Will Drake
- Mommy - Will Drake
- Room 33 - Will Drake
- Flicker - Will Drake
- She Wants Revenge - Will Drake
- She Gets Revenge - Will Drake
- Battle Royale - Will Drake
- Be Our Guest - Will Drake
- Chapter 3 - Sidney Aaron James (voice only)
- Chapter 4 - Sidney Aaron James (voice only)
- Chapter 5 - Sidney Aaron James (voice only)
- Chapter 6 - Sidney Aaron James
- Chapter 7 - Sidney Aaron James
- Chapter 9 - Sidney Aaron James
- Chapter 10 - Sidney Aaron James
- Election Night - Dr. Rudy Vincent
- Don't Be Afraid of the Dark - Dr. Rudy Vincent
- Neighbors From Hell - Dr. Rudy Vincent
- 11-9 - Dr. Rudy Vincent
- Holes - Dr. Rudy Vincent
- Mid-Western Assassin - Dr. Rudy Vincent
- Winter of Our Discontent - Dr. Rudy Vincent
- Charles (Manson) in Charge - Dr. Rudy Vincent
- Could It Be... Satan? - John Henry Moore
- Boy Wonder - John Henry Moore
- Traitor - John Henry Moore
- Fire and Reign - John Henry Moore