Cheyenne Jackson had started off his acting career in Seattle and then moved to New York where he was an understudy for Thoroughly Modern Millie and Aida. He then starred as Matthew in Altar Boyz. Later on, he got the leading role on Broadway in All Shook Up and won a theater world award for it. Since then he has come out in bigger movies and has earned an Academy Award nomination for United 93.
- Jackson was dubbed by the NY Post as Broadway's sexiest man.
- Jackson had previously worked for Ryan Murphy, with the role of Dustin Goolsby, the coach of "Vocal Adrenaline", on the second season of Glee.
- He is one of the six members of the AHS Repertory Company to be credited in the main cast in every season he appeared in.
- All characters he portrayed in American Horror Story violently died before the end of each season they appeared on. Coincidentally, three of them died after having their throats slit. Two of them were murdered by characters portrayed by Kathy Bates.