Jamie Brewer made her television debut on American Horror Story. Prior to her transition to acting on camera, she was a theatrical actress. She has not left the stage, however, and still continues her training through theater and through improvisation at 'The Groundlings Theatre and School'.
Jamie started taking theatre classes in 1999 at a 'College for Kids' class during her middle school years. Jamie has performed in dramas, musicals, comedy's, and improvisations during her theatre training at Dionysus Theatre. Jamie appeared/spoke in PSA's for the "Souper Bowl of Caring Houston Food Drive" in Houston, TX for 2 consecutive years which aired on NBC, ABC, and CBS.
Being an individual with Down Syndrome Jamie has made it a point to be active in the Down Syndrome community. Jamie was the youngest to ever be elected President of the ARC of Fort Bend Chapter. From there, she was appointed to the State of Texas ARC Board, then elected to the Executive Board as Treasurer. Jamie was then asked to serve on the ARC Governmental Affairs Committee for the State of Texas. She spoke with Senators at the Texas State Capitol to persuade them to pass the law for Texas to abolish using the "R" word from state legislation, and regarding the needs of people with disabilities in Texas. Texas now uses "Intellectual Developmental Disability" in their legislation.
Brewer is involved with several non-profit organizations, including DSALA, DSiAM, BTAP, National Down Syndrome Congress, American Association of People with Disabilities of the United States, and Civitan International. 
- Jamie Brewer is one of the twenty-four cast members that portrayed the same character in different seasons. She portrayed Nan in Coven and Apocalypse.
- The others are Angela Bassett , Christine Estabrook, Connie Britton, Dylan McDermott, Emma Roberts, Evan Peters , Frances Conroy, Gabourey Sidibe, Jessica Lange, John Carroll Lynch, John Cromwell, Kathy Bates, Lance Reddick , Lily Rabe, Matt Ross, Naomi Grossman, Mena Suvari , Riley Schmidt, Sam Kinsey , Sarah Paulson, Stevie Nicks, Taissa Farmiga and Wayne Pére .