Mädchen Amick is perhaps best known for playing Shelly Johnson on the cult television series Twin Peaks and its 1992 prequel film Twin Peaks: Fire Walk with Me. She also starred as Wendy Beauchamp in the Lifetime supernatural drama series Witches of East End for two seasons (2013–2014). She had a leading role in the prime-time soap Central Park West and the 1998 revival of Fantasy Island. She has had recurring roles in Dawson's Creek, Gilmore Girls, ER, Joey, Gossip Girl, Californication, My Own Worst Enemy, Damages, CSI: NY, and Longmire.
- Amick worked as a model for Elite Agency after leaving home for Los Angeles at age 16.